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Total shareholder return


The Regulations require the inclusion of a graph showing total shareholder return (TSR) over a five-year period in respect of a holding of the Company's shares, plotted against TSR in respect of a hypothetical holding of shares of a similar kind and number by reference to which a broad equity market index is calculated. The Company is a member of the FTSE 100 Index and consequently, for the purposes of this graph, which is set out below, we have selected the FTSE 100 Index as the appropriate index. This graph is re-based to 100 at the start of the rolling five-year period. We have also included a 'Pharma Peers Average' (excluding Schering-Plough Corporation and Wyeth Inc.), which reflects the TSR of the same comparator group used for the PSP graphs below.

The PSP requires that the TSR in respect of a holding of the Company's shares over the relevant performance period be compared with the TSR of a peer group of pharmaceutical companies (as described in the Performance targets section). The graphs below show how the Company's TSR performance has compared with the TSR for the relevant companies in the comparator group from the first day in the relevant three-year performance period in respect of each Share Award to 31 December 2009 and how the Company ranks against those other companies on this basis.

To alleviate any short-term volatility, the return index is averaged in the TSR calculations for each company over the three months prior to the start of the relevant performance period (as stipulated in the PSP) and, for the purposes of the graphs below, over the last three months of 2009.

TSR over a five-year period

TSR - AstraZeneca compared with peer group 1 Jan 2007 to 31 Dec 2009 (for the 2007 award) %

TSR - AstraZeneca compared with peer group 1 Jan 2008 to 31 Dec 2009 (for the 2008 award) %

TSR - AstraZeneca compared with peer group 1 Jan 2009 to 31 Dec 2009 (for the 2009 award) %

AstraZeneca
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"We are focused on the discovery, development and commercialisation of prescription medicines for six important areas of healthcare"

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AstraZeneca Annual Report and Form 20-F Information 2009

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