AstraZeneca Annual Report and Form 20-F Information 2008

AstraZeneca PLC Board composition, processes & responsibilities

The Board comprises three Executive Directors (two from April 2009 when John Patterson’s retirement takes effect) and 11 Non-Executive Directors. The membership of the Board at 31 December 2008, and information about individual Directors is contained in the Board of Directors section.

BOARD AND SENIOR MANAGEMENT bod_flowchart

BALANCE OF NON-EXECUTIVE DIRECTORS AND EXECUTIVE DIRECTORS 8 Independent Non-Executive Directors, 3 Executive Directors, 2 Non-Independent Non-Executive Directors, 1 Chairman

8 Independent Non-Executive Directors, 3 Executive Directors, 2 Non-Independent Non-Executive Directors, 1 Chairman

LENGTH OF TENURE OF NON-EXECUTIVE DIRECTORS 5 0-3 years, 2 3-6 years, 4 6-9 years

GENDER SPLIT OF DIRECTORS

11 male, 3 female

GEOGRAPHICAL MIX OF NON-EXECUTIVE DIRECTORS 5 Europe, 3 UK, 3 US

¹ As determined by the Board in accordance with the UK Combined Code

All Directors are collectively responsible for the success of the Company. The Non-Executive Directors have a responsibility to bring independent, objective judgement to bear on Board decisions, which includes constructively challenging management and helping to develop the Company’s strategy as well as scrutinising the performance of management. The Non-Executive Directors also have various responsibilities concerning the integrity of financial information, internal controls and risk management.

At the end of every Board meeting, the Company’s Non-Executive Directors meet without the Executive Directors present in order to review and discuss any matters that have arisen during the meeting and/or such other matters as may appear to the Non-Executive Directors to be relevant to them in properly discharging their duties independently. To ensure the Board has good visibility of the key operating decisions of the business, members of the SET routinely attend Board meetings on a rotational basis and the Board regularly meets and consults other senior employees throughout the year.

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