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Board of Directors

LOUIS SCHWEITZER

LOUIS SCHWEITZER (66)

Non-Executive Chairman, Chairman of the Nomination and Governance Committee and Member of the Remuneration Committee

Appointed as a Director 11 March 2004. Non-Executive Chairman of Renault SA since April 2005. Chairman and Chief Executive Officer of Renault SA 1992-2005. Non-Executive Director of BNP-Paribas, Veolia Environnement, Volvo AB and L’Oréal.

DAVID BRENNAN

DAVID BRENNAN (55)

Executive Director and Chief Executive Officer

Appointed as a Director 14 March 2005. Appointed Chief Executive Officer 1 January 2006. Chairman-elect of the Executive Board of the Pharmaceutical Research and Manufacturers of America (PhRMA) (to take effect on 3 April 2009). Honorary Board Member of the US CEO Roundtable on Cancer, Board Member of the European Federation For Pharmaceutical Industries and Associations (EFPIA). Commissioner of the UK Commission for Employment and Skills (UKCES). Chairman of the Board of the Southeastern Chapter of the American Heart Association 2004-2006.

SIMON LOWTH

SIMON LOWTH (47)

Executive Director and Chief Financial Officer

Appointed as a Director 5 November 2007. Also has overall responsibility for Information Services. Finance Director, Scottish Power plc 2005-2007 and Executive Director, Corporate Strategy and Development, Scottish Power plc 2003-2005. Director – Head of UK Industrial Practice, McKinsey & Company 2000-2003.

MARCUS WALLENBERG

MARCUS WALLENBERG (52)

Non-Executive Director

Appointed as a Director 6 April 1999. Formerly a Director of Astra AB (appointed 18 May 1989). Chairman of Skandinaviska Enskilda Banken AB. Chairman of AB Electrolux. Chairman of SAAB AB. Vice-Chairman of Telefonaktiebolaget
L M Ericsson. Non-Executive Director of Stora Enso Oyj, the Knut and Alice Wallenberg Foundation and Temasek Holdings Ltd. Honorary Chairman of International Chamber of Commerce.

JOHN VARLEY

JOHN VARLEY (52)

Non-Executive Director, Chairman of the Remuneration Committee and Member of the Nomination and Governance Committee

Appointed as a Director 26 July 2006. Executive Director of Barclays Bank plc and Barclays plc since 1998 and Group Chief Executive since 2004. Chairman of Business Action on Homelessness and President of the Employers’ Forum on Disability and member of the International Advisory Panel of the Monetary Authority of Singapore. Honorary President of the UK Drug Policy Commission. Treasurer and Trustee of St. Dunstan’s and Trustee of Thornton Smith & Plevins Young People’s Trust.

JOHN BUCHANAN

JOHN BUCHANAN (65)

Non-Executive Director, Chairman of the Audit Committee and Member of the Remuneration Committee

Appointed as a Director 25 April 2002. Executive Director and Group Chief Financial Officer of BP p.l.c. 1996-2002. Member of the UK Accounting Standards Board 1997-2001. Senior Independent Director of BHP Billiton Plc. Deputy Chairman of Vodafone Group Plc. Chairman of Smith & Nephew plc. Chairman of International Chamber of Commerce (UK).

JOHN PATTERSON CBE FRCP

JOHN PATTERSON CBE FRCP (60)

Executive Director, Development and Member of the Science Committee

Appointed as a Director 1 January 2005. Fellow of the Royal College of Physicians. Director of the British Pharma Group. Non-Executive Director of Cobham plc. Non-Executive Director of Amersham plc 2001-2004. President of the Association of the British Pharmaceutical Industry (ABPI) 2002-2004. Member of the Supervisory Board of the UK Medicines Control Agency 1990-1994.

HÅKAN MOGREN KBE

HÅKAN MOGREN KBE (64)

Non-Executive Deputy Chairman and Member of the Nomination and Governance Committee

Appointed as a Director 6 April 1999. Formerly Chief Executive Officer and a Director of Astra AB (appointed 18 May 1988). Member of the Board of Directors of Investor AB and Groupe Danone. Director of the Marianne and Marcus Wallenberg Foundation. Member of the Royal Swedish Academy of Engineering Sciences.

MICHELE HOOPER

MICHELE HOOPER (57)

Senior Non-Executive Director, Member of the Audit Committee and the Nomination and Governance Committee

Appointed as a Director 1 July 2003. President and Chief Executive Officer of Stadtlander Drug Company 1998-1999. Corporate Vice-President and President, International Businesses of Caremark International Inc. 1992-1998. Non-Executive Director of UnitedHealth Group, PPG Industries, Inc. and Warner Music Group, Inc.

DAME NANCY ROTHWELL

DAME NANCY ROTHWELL (53)

Non-Executive Director, Chairman of the Science Committee and Member of the Remuneration Committee

Appointed as a Director 27 April 2006. Also has responsibility for overseeing Corporate Responsibility. MRC Research Professor and Deputy President and Deputy Vice Chancellor at the University of Manchester. Council member of the Biotechnology and Biological Sciences Research Council, Vice-President and Council member of the Royal Society. Prior appointments include: Trustee of Cancer Research UK and the Campaign for Medical Progress; Chair of the Research Defence Society; Chair of the Wellcome Trust Public Engagement Strategy Panel; President of the British Neuroscience Association; and Council member of the Medical Research Council.

JANE HENNEY

JANE HENNEY (61)

Non-Executive Director, Member of the Audit Committee, the Nomination and Governance Committee and the Science Committee

Appointed as a Director 24 September 2001. Currently Professor of Medicine, University of Cincinnati. Prior appointments include: Senior Vice-President and Provost for Health Affairs, University of Cincinnati Medical Academic Health Center; Deputy Director, US National Cancer Institute; Deputy Commissioner for Operations, US Food and Drug Administration (FDA); and Commissioner of Food and Drugs, FDA. Non-Executive Director of AmerisourceBergen Corporation and CIGNA Corporation. Other board appointments include The Commonwealth Fund and China Medical Board.

BO ANGELIN

BO ANGELIN (59)

Non-Executive Director and Member of the Science Committee

Appointed as a Director 24 July 2007. Professor of Clinical Metabolism at Karolinska Institutet and Head of the Department of Endocrinology, Metabolism and Diabetes at the Karolinska University Hospital in Stockholm, Sweden. Member of the Nobel Assembly and of the Swedish Royal Academy of Sciences. Member of the Medical Nobel Institute. Prior appointments include Chairman of the Nobel Committee for Physiology and Medicine.

Jean-Philippe COURTOIS

Jean-Philippe COURTOIS (48)

Non-Executive Director and Member of the Audit Committee

Appointed as a Director 18 February 2008. President of Microsoft International since June 2005. CEO Microsoft EMEA 2003-2005. President Microsoft EMEA 2000-2003. Corporate Vice-President, Microsoft Worldwide Customer Marketing 1998-2000. Administrator for PlaNet Finance and representative at the Institut Montaigne.

RUDY MARKHAM

RUDY MARKHAM (62)

Non-Executive Director and Member of the Audit Committee

Appointed as a Director 12 September 2008. Chairman and Non-Executive Director of Moorfields Eye Hospital Foundation Trust. Non-Executive Director of United Parcel Services Inc., Financial Reporting Council, Standard Chartered PLC and Legal & General plc. Fellow of the Chartered Institute of Management Accountants and Fellow of the Association of Corporate Treasurers.

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