AstraZeneca Annual Report and Form 20-F Information 2008

Percentage analysis at 31 December 2008 of issued share capital

By size of account No. of shares	2008 %
1 – 250	0.5
251 – 500	0.7
501 – 1,000	0.9
1,001 – 5,000	1.2
5,001 – 10,000	0.2
10,001 – 50,000	1.0
50,001 – 1,000,000	13.6
Over 1,000,0001	81.9
Issued share capital	100.0

¹ Includes VPC and ADR holdings.

At 31 December 2008, AstraZeneca PLC had 135,790 registered holders of 1,447,481,548 Ordinary Shares of $0.25 each. At 31 December 2008, there were approximately 52,000 holders of American Depositary Receipts (ADRs) representing 7.36% of the issued share capital and 146,000 holders of shares held under the VPC Services Agreement representing 17.83% of the issued share capital. The ADRs, each of which is equivalent to one Ordinary Share, are issued by JPMorgan Chase Bank.