AstraZeneca Annual Report and Form 20-F Information 2008

F-M

The following abbreviations and expressions have the following meanings when used in this report:

finance income and expense This includes interest earned and payable, and similar items.

first good laboratory practice (FGLP) The point at which a compound undergoes the first pre-clinical study that is required for regulatory approval; this marks entry into the development pipeline.

first-line therapy Treatment given to a newly diagnosed patient, who has therefore not yet been treated; it is the initial treatment of a disease, sign or symptom.

Food and Drug Administration (FDA) Part of the US Department of Health and Human Services Agency, which is the regulatory authority for all pharmaceuticals (including biologics and vaccines) and medical devices in the US.

generalised anxiety disorder (GAD) A neurotic illness characterised by chronic and persistent apprehension and tension.

gross margin The margin, as a percentage, by which sales exceed the cost of sales, calculated by dividing the difference between the two by the sales figure.

Group AstraZeneca PLC and its subsidiaries.

high-density lipoprotein cholesterol (HDL-C) Cholesterol carried in the blood by HDL back to the liver, sometimes referred to as ‘good’ cholesterol.

hsCRP A high-sensitivity C-Reactive Protein to determine the potential risk for cardiovascular disease (measures levels of C-Reactive Protein in the blood).

IAS International Accounting Standards.

IFRS International Financial Reporting Standards.

KPI Key performance indicator.

large molecule A general term used to describe pharmaceutical R&D using biology and biological methods and materials to discover and develop new medicines. Biological molecules are large compared with chemical molecules.

LIBID London Interbank Bid Rate.

low-density lipoprotein cholesterol (LDL-C) Cholesterol that is carried in the blood by LDL, sometimes referred to as ‘bad’ cholesterol.

LSE London Stock Exchange plc.

MAb (Monoclonal antibody) A large molecule that is extremely specific; that is, it binds to and attacks one particular antigen.

major depressive disorder (MDD) Depression where five or more symptoms of depression are present for at least two weeks.

marketing authorisation application (MAA) An application for authorisation to place medical products on the market. This is a specific term for the EU and European Economic Area (EEA) markets.

Medicare A US health insurance programme for US citizens aged 65 or older, US citizens under age 65 with certain disabilities and US citizens of all ages with permanent kidney failure requiring dialysis or a kidney transplant. Recently, Medicare began offering prescription drug coverage under Part D of the Medicare Prescription Drug Benefit Program.

moving annual total (MAT) A figure that represents the financial value of a variable for 12 months.

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