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Remuneration Report

Total Shareholder Return graphs

The UK Directors’ Remuneration Report Regulations 2002 require the inclusion in the Directors’ Remuneration Report of a graph showing total shareholder return (TSR) over a five year period in respect of a holding of the Company’s shares, plotted against TSR in respect of a hypothetical holding of shares of a similar kind and number by reference to which a broad equity market index is calculated. The Company is a member of the FTSE 100 Index and consequently, for the purposes of this graph, which is set out below, we have selected the FTSE 100 Index as the appropriate index. This graph is re-based to 100 at the start of the rolling five-year period. We have also included a ‘Pharma Peers Average’, which reflects the TSR of the same comparator group used for the Performance Share Plan graphs below.

The AstraZeneca Performance Share Plan (PSP) requires that the TSR in respect of a holding of the Company’s shares over the relevant performance period be compared with the TSR of a peer group of 12 other pharmaceutical companies. The graphs below show how the Company’s TSR performance has compared with the TSR for the companies in the comparator group from the first day in the relevant three-year performance period in respect of each Award to 31 December 2007 and how the Company ranks against those other companies on this basis.

To alleviate any short-term volatility, the return index is averaged in the TSR calculations for each company over the three months prior to the start of the relevant performance period (as stipulated in the PSP) and, for the purposes of the graphs below, over the last three months of 2007.

TSR OVER A FIVE YEAR PERIOD

Graph showing TSR variance over a five year period

TSR – ASTRAZENECA COMPARED WITH PEER GROUP 1 JAN 2005 TO 31 DEC 2007 (FOR THE 2005 AWARD)

TSR – ASTRAZENECA in 9th PLACE COMPARED WITH PEER GROUP 1 JAN 2005 TO 31 DEC 2007  (FOR THE 2005 AWARD)

TSR – ASTRAZENECA COMPARED WITH PEER GROUP 1 JAN 2006 TO 31 DEC 2007 (FOR THE 2006 AWARD)

TSR – ASTRAZENECA in 13th PLACE COMPARED WITH PEER GROUP 1 JAN 2006 TO 31 DEC 2007  (FOR THE 2006 AWARD)

TSR – ASTRAZENECA COMPARED WITH PEER GROUP 1 JAN 2007 TO 31 DEC 2007 (FOR THE 2007 AWARD)

TSR – ASTRAZENECA in 13th PLACE COMPARED WITH PEER GROUP 1 JAN 2007 TO 31 DEC 2007  (FOR THE 2007 AWARD)

Source data for all graphs on this page: Thomson Financial Datastream.

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