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Directors' Report:
Business Review

Chief Executive Officer, Delegation of Authority and Senior Executive Team

DAVID BRENNAN

DAVID BRENNAN

Chief Executive Officer

SIMON LOWTH

SIMON LOWTH

Chief Financial Officer

JOHN PATTERSON CBE FRCP

JOHN PATTERSON CBE FRCP

Executive Director, Development

TONY ZOOK

TONY ZOOK

President and Chief Executive Officer, North America and Executive Vice-President, Global Marketing

DAVID SMITH

DAVID SMITH

Executive Vice-President,
Operations

DAVID MOTT

DAVID MOTT

President and Chief Executive Officer, MedImmune

LYNN TETRAULT

LYNN TETRAULT

Executive Vice-President, Human Resources and Corporate Affairs

BRUNO ANGELICI

BRUNO ANGELICI

Executive Vice-President, Europe, Japan, Asia Pacific and Rest of the World

JAN LUNDBERG

JAN LUNDBERG

Executive Vice-President, Discovery Research

Chief Executive Officer and delegation of authority

The Chief Executive Officer has been delegated authority from, and is responsible to, the Board of AstraZeneca PLC for directing and promoting the profitable operation and development of the Company, consistent with the primary aim of enhancing long-term shareholder value, in relation to all matters save those which have been specifically reserved for the Board. Further information on the operation of the Board can be found in the Corporate Governance and Managing Risk section.

The Chief Executive Officer is responsible to the Board for the management and performance of the Company’s businesses within the framework of Company policies, reserved powers and routine reporting requirements. He is obliged to refer certain major matters (defined in the formal delegation of the Board’s authority) back to the Board. The roles of the Board and the relationship between each of the Board’s committees, the Chairman, the Chief Executive Officer and the Senior Executive Team are documented, as are the Board’s delegated authorities and reserved powers, the means of operation of the business and the roles of corporate functions.

Senior Executive Team (SET)

The Chief Executive Officer has established and chairs the SET (pictured above). Although the Chief Executive Officer retains full responsibility for the authority delegated to him by the Board, the SET is the vehicle through which he has chosen to exercise certain of that authority in respect of the Company’s business (including MedImmune, Arrow Therapeutics, KuDOS, Aptium Oncology and Astra Tech). The SET normally meets once a month to consider and decide major business issues. Typically, it also reviews those matters that are of a size or importance to require the attention of, or that are reserved to, the Board before such matters are submitted to the Board for review and decision.

During 2007, Jonathan Symonds, formerly Chief Financial Officer, resigned to pursue his career outside AstraZeneca. Simon Lowth was appointed as our new Chief Financial Officer and joined the Company and the Board in November 2007. Also during the year, Martin Nicklasson, formerly Executive Vice-President, Global Marketing, resigned to pursue his career outside AstraZeneca and Tony Bloxham, formerly Executive Vice-President, Human Resources, retired. Their responsibilities have been assumed by Tony Zook and Lynn Tetrault, respectively.

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