AstraZeneca PLC Board composition, processes and responsibilities

The Board comprises three Executive Directors and nine Non-Executive Directors. See the Board of Directors section for the membership of the Board at 31 December 2007, and information about individual Directors.

Board of Directors, Non Executive Chairman and Non-executive Directors - Chief executive officer and other Executive Directors: Board Committees, (Audit Comittee, Nomination Comittee, and Science Comittee): Chief Executive Office: Senior Executive Team: R&D Comittee

All Directors are collectively responsible for the success of the Company. The Non-Executive Directors have a responsibility to bring independent, objective judgement to bear on Board decisions, which includes constructively challenging management and helping to develop the Company’s strategy as well as scrutinising the performance of management. The Non-Executive Directors also have various responsibilities concerning the integrity of financial information, internal controls and risk management.

At the end of every Board meeting the Company’s Non-Executive Directors meet without the Executive Directors present in order to review and discuss any matters that have arisen during the meeting and/or such other matters as may appear to the Non-Executive Directors to be relevant to them in properly discharging their duties in an independent manner. In order to ensure that the Board has good visibility in respect of the key operating decisions of the business, members of the SET routinely attend Board meetings on a rotational basis and the Board regularly meets and consults other senior employees throughout the year.

Further details about the members and responsibilities of the SET are described in the Chief Executive Officer, Delegation of Authority & Senior Executive Team section. Further information about the operation of the Board and its committees can be found in the Corporate Governance and Managing Risk section.